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教授

     

    马龙,男,1983年生,教授,博导。先后主持和参加了多个中国、英国和欧盟的科研基金项目,总额大于210万英镑。回国后主持国家自然基金青年、面上项目等。2014年5月入职天津科大任副教授,2015年10月起任教授,2017年任博士生导师。
    近年先后发表31篇SCI文章,其中26篇发表于JCR I、II区杂志。文章总影响因子约150,影响因子>5分8篇,其中第一作者/通讯作者6篇。影响因子>9分4篇,其中第一作者3篇。单篇文章最高影响因子11.4,单篇第一作者文章最高被SCI引用67次。发表的文章曾被国际著名期刊Chem. Rev. (IF=45.6),Nat. Nanotechnol. (IF=33.3),Acc. Chem. Res. (IF=24.3) 等引用。文章被2012年4月11日出版的美国化学会志 (IF=11.4) 作为封面进行报道。2014年发表在ChemBioChem的文章被当年2月3日出版的美国化学会著名的科学传播杂志《化学和工程新闻》(C&E News) 作为“亮点”报道;并被评选为ChemBioChem杂志 (JCR二区) “Most-accessed articles published in ChemBioChem during 2015”。2014年发表在Journal of Ethnopharmacology的药理学文章被美国医生网MDLinx作为“推荐”文章报道。现申请中国专利4项。
    获得中国国家留学基金委奖学金 (CSC scholarship),英国爱丁堡大学MTEM科研奖励,英国爱丁堡大学化学院奖学金,英国爱丁堡大学会议奖学金 (conference grant),欧洲科学研究委员会博士后研究基金奖励等。多次参加国际核酸生物和化学年会、英国皇家化学会组织的学术研讨会,并在大会上做口头及墙报展示。

教育及工作背景:
2002.09-2006.07 天津医科大学 药剂学 学士 (Bsc)
2006.09-2008.07 天津大学药物科学与技术学院 药剂学 硕士 (Msc)
2008.09-2011.11 英国爱丁堡大学 生物物理化学 博士 (PhD)
2011.11-2014.04 英国圣安德鲁斯大学 生物医学研究中心 研究员 (Research Fellow)

主讲课程:
本科生:分子生物学;微生物遗传学与育种 (双语)
研究生:制药工程专题讲座;新药研究与开发;科技论文写作等

所获奖励:
2008年国家留学基金委CSC奖学金
2008年英国爱丁堡大学MTEM奖学金
2008年爱丁堡大学化学院奖学金
2012年欧洲研究理事会ERC博士后基金
2014年“海河学者”培育计划
2016年天津市创新人才推进计划“青年科技优秀人才”
2016年天津市创新人才推进计划“重点领域创新团队” (参与)
2017年度天津市创新创业创优先进个人
2017年度入选天津市高校“中青年骨干创新人才培养计划”

社会兼职:
应邀作为BMC Mol. Bio.,Curr. Cancer Drug Tar.,ChemBioChem,Anticancer Agents Med. Chem.,Inflammation,BMC Complement Altern. Med.,Pharmacogn. Mag.,RSC Advances等数十种著名专业期刊的审稿人;2015年收到Current Medicinal Chemistry (JCR二区,IF = 3.853) 特约编辑邀请;
《Traditional Medicine Research》杂志编委;
中国微生物学会会员;
天津市药学会会员,天津市药学会青委会委员;
天津市科委、河北省科委项目评审专家等。

招收研究生方向:欢迎具有药学、化学、化工、食品及医学等背景学生报考本课题组硕士和博士研究生。我们2018计划年招收2名博士研究生和约5名硕士研究生。我们拥有充足的实验资金,为学生提供良好的实验条件与悉心的指导,激发学生潜能,靠脚踏实地的工作成就未来。

科研领域及方向:
1.基于核酸、核酸相关酶、核酸适体和纳米材料的生物传感器研究,用于生物样品的分析和药品、食品质量控制。
2. 基于天然活性产物的抗肿瘤、抗炎活性物质发现及药理学评价;靶向人类核酸修复系统抑制剂的发现和抗肿瘤活性评价。
3. 链霉菌中的生物催化、生物合成及代谢研究。新型生物催化剂 (酶) 的发现、设计和利用;生物催化路线和次级活性代谢产物生物合成途径的研究;链霉菌中活性天然的发现。

代表性论文/著作:
1. Long Ma and Scott L. Cockroft* Biological nanopores for single-molecule biophysics. ChemBioChem, 2010, 11, 25-34. (IF=3.945,JCR二区) 
2. Craig P. Wilson, Cécile Boglio, Long Ma, Scott L. Cockroft and Simon J.Webb* Palladium(II)-mediated assembly of biotinylated ion channels. Chemistry−A European Journal, 2011, 17, 3465-3473. (IF=5.476,JCR二区) 
3.Tara Sabir, Anita Toulmin, Long Ma, Anita C. Jones, Peter McGlynn, Gunnar F. Schroder* and Steven W. Magennis* Branchpoint expansion in a fully complementary three-way DNA junction. Journal of the American Chemical Society, 2012, 134, 6280-6285. (IF=11.336,JCR一区) “featured as cover art” (被选为封面报道)  
4.Long Ma, Kai Chen, David J. Clarke, Christopher P. Nortcliffe, Geoffrey G. Wilson, J. Michael Edwardson, A. Jennifer Morton, Anita C. Jones and David T. F. Dryden* Restriction endonuclease TseI cleaves A:A and T:T mismatches in CAG and CTG repeats. Nucleic Acids Research, 2013, 41, 4999-5009. (IF=9.202,JCR一区) 
5. L. David Finger#, Nikesh Patel#, Amanda Beddows#, Long Ma# (共同第一作者), Jack C. Exell#, Emma Jardine, Anita C. Jones* and Jane A. Grasby* Observation of unpaired substrate DNA in the flap endonuclease-1 active site. Nucleic Acids Research, 2013, 41, 9839-9847. (IF=9.202,JCR一区) 
6. Long Ma, Xiaohua Wu, Geoffrey G. Wilson, Anita C. Jones and David T.F. Dryden* Time-resolved fluorescence of 2-aminopurine in DNA duplexes in the presence of the EcoP15I Type III restriction-modification enzyme. Biochemical and Biophysical Research Communications, 2014, 449, 120-125. (IF=2.281,JCR二区) 
7. Hai Deng,*# Long Ma# (共同第一作者), Nouchali Bandaranayaka, Zhiwei Qin, Greg Mann, Kwaku Kyeremeh, Yi Yu, Thomas Shepherd, James H. Naismith and David O’Hagan* Identification of fluorinases from Streptomyces sp. MA37, Norcardia brasiliensis, and Actinoplanes sp. N902-109 by genome mining. ChemBioChem, 2014, 15, 364-368. (IF=3.945,JCR二区) “highlighted in ACS C&E News, Volume 92 Issue 5,Feb 3, 2014, p. 25-26” 被美国化学会化学与工程新闻作为“重点”报道;被评选为ChemBioChem杂志“Most-accessed articles published in ChemBioChem during 2015”。
8.Sheng Huang#, Long Ma# (共同第一作者), Ming Him Tong, Yi Yu,* David O’Hagan and Hai Deng* Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674. Organic & Biomolecular Chemistry, 2014, 12, 4828-4831. (IF=3.487,JCR二区) 
9. Long Ma* and Jiangguang Liu The protective activity of Conyza blinii saponin against acute gastric ulcer induced by ethanol. Journal of Ethnopharmacology, 2014, 158, Part A, 358-363. (IF=2.939,*通讯作者,JCR二区) “featured in MDLinx.com” 被美国医生网MDLinx作为“推荐”文章报道。 
10. Long Ma, Axel Bartholome, Ming Him Tong, Zhiwei Qin, Yi Yu, ThomasShepherd, Kwaku Kyeremeh, Hai Deng* and David O’Hagan* Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-trihydroxypentanoic acid. Chemical Science, 2015, 6, 1414-1419. (IF=9.211,JCR一区)  
11. Long Ma*, and Aipo Diao Marizomib, A potent second generation proteasome inhibitor from natural origin. Anti-cancer Agents in Medicinal Chemistry, 2015, 15, 298-306. (IF=2.939,*通讯作者,JCR二区)  
12.Long Ma*, and Aipo Diao Design enzyme-interfaced DNA logic operations (AND, OR and INHIBIT) with an assaying application for single-base mismatch. Chemical Communications, 2015, 51, 10233-10235. (IF=6.834,*通讯作者,JCR一区)  
13.Long Ma*, Guanrong Wu, Yufeng Li, Ping Qin, Lingpei Meng, Haiyan Liu, Yuyin Li and Aipo Diao A reversible metal ions fueled DNA molecular device for “turn-on and -off” fluorescence detection of mercury ions (II) and biothiols respectively with high selectivity and sensitivity. Nanoscale, 2015, 7, 18044-18048. (IF=7.760,*通讯作者,JCR一区)
14.Long Ma*, Yufeng Li, Lingpei Meng, Hai Deng, Yuyin Li, Qiang Zhang and Aipo Diao Biological fluorination from the sea: Discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674. RSC Advances, 2016, 6, 27047-27051. (IF=3.840,*通讯作者,JCR二区) 
15.Long Ma*, Haiyan Liu, Guanrong Wu, Nana Sun, Lingpei Meng, Yuyin Li, Zhenxing Liu and Aipo Diao A dual-channel detection of mercuric ions using a label free G-quadruplex-based DNAzyme molecule. Analyst, 2016, 141, 3997-4000. (IF=4.107,*通讯作者,JCR一区)
16. Jing Liua, Shuli Man, Zhen Liu, Long Ma, Wenyuan Gao A synergistic antitumor effect of polyphyllin I and formosanin C on hepatocarcinoma cells. Bioorganic & Medicinal Chemistry Letters, 2016, 26, 4970-4975. (IF=2.486,JCR三区)
17. Curcumin-cyclodextrin complexes enhanced the anti-cancer effects of curcumin. Environmental Toxicology and Pharmacology, 2016, 48, 31-38. (IF=2.187,JCR三区)
18. Inhibition of urethane-induced lung carcinogenesis in mice by a Rhizoma paridis saponin involved EGFR/PI3K/Akt pathway. RSC Advances, 2016, 6, 92330-92334. (IF=3.289,JCR二区)
19. Long Ma*, Haiyan Liu, Lingpei Meng, Ping Qin, Botao Zhang, Yuyin Li, Shuli Man, Zhen Liu, Zhenxing Liu and Aipo Diao Evaluation of the anti-cancer activity of the triterpenoidal saponin fraction isolated from the traditional Chinese medicine Conyza blinii H. Lév. RSC Advances, 2017, 7, 3408-3412. (IF=3.289,*通讯作者,JCR二区)
20.Metabolic regulatory network alterations reveals different therapeutic effects of cisplatin and Rhizoma paridis saponins in Lewis pulmonary adenoma mice. RSC Advances, 2016, 6, 115029-115038. (IF=3.289,*通讯作者,JCR二区)
21. Lysosome inhibitors enhance the chemotherapeutic activity of Doxorubicin in HepG2 cells. Chemotherapy, 2016, 62, 85-93. (IF=0.992,JCR四区)
22.Sp1 transcription factor promotes TMEPAI gene expression and contributes to cell proliferation. Cell Proliferation, 2016, 49, 710-719. (IF=3.084,JCR三区)
23. Long Ma*, Haiyan Liu, Ping Qing, Chenxi Hu, Shuli Man, Yuyin Li, Zhen Liu, Zhenxing Liu, Aipo Diao Saponin fraction isolated from Conyza blinii H.Lév. demonstrates strong anti-cancer activity that is due to its NF-κB inhibition. Biochemical and Biophysical Research Communications, 2017, 483, 779-785. (IF=2.371,*通讯作者,JCR二区)
24.Inhibition of lung cancer in diethylnitrosamine-induced mice by Rhizoma paridis saponins. Molecular Carcinogenesis, 2017, 56, 1405–1413. (IF=4.722,JCR二区)
25.Curcumin Attenuates N-Nitrosodiethylamine-Induced liver injury in mice by utilizing the method of metabonomics. Journal of Agriculture and Food Chemistry, 2017, 65, 2000-2007. (IF=3.154,JCR一区)
26.Haiyan Liu, Chenxi Hu, Nana Sun, Yuyin Li, Shuli Man, Zhenxing Liu, Aipo Diao and Long Ma* A triterpenoidal saponin fraction of Conyza blinii H.Lév. is a dual-targeting autophagy inhibitor for HeLa cells. RSC Advances, 2017, 7, 24291 - 24297. (IF=3.289,*通讯作者,JCR二区)
27.Long Ma*, Nana Sun, Chunhao Tu, Qian Zhang, Aipo Diao* Design an aptamer-based fluorescence displacement biosensor for selective and sensitive detection of kanamycin in aqueous- samples. RSC Advances, 2017, 7, 38512-38518. (IF=3.289,*通讯作者,JCR二区)
28.Shuli Man, Jiang Ma, Jingwen Yao, Jingxia Cui, Chunxia Wang, Yu Li, Long Ma*, and Fuping Lu* Systemic perturbations of key metabolites in Type 2 diabetic rats treated by polyphenols extracts from Litchi chinensis seeds. Journal of Agriculture and Food Chemistry, 2017, 65 , 7698–7704. (IF=3.154,JCR一区)
29. Low density lipoprotein receptor class A domain containing 4 (LDLRAD4) promotes tumorigenesis of hepatic cancer cells. Experimental Cell Research, 2017, 360, 189-198. (IF=3.546,JCR 二区)
30. Antitumor and anti-metastatic mechanisms of Rhizoma paridis saponins in Lewis mice.  Environmental Toxicology, 2017, accepted. (IF=2.937,JCR 二区)
31. Long Ma,* Nana Sun, Jinyan Zhang, Chunhao Tu, Xiuqi Cao, Demin Duan, Aipo Diao*, Shuli Man* Polyethylenimine-coated Fe3O4 nanoparticles effectively quench fluorescent DNA, which can be developed as a novel platform for protein detection. Nanoscale, 2017, 9, 17699-17703. (IF=7.760,*通讯作者,JCR一区)
  
指导本科生和研究生获奖:
2014年指导本科生参加天津市第四届大学生生命科学基本实验技能竞赛获一等奖。
2015年指导本科生参加“挑战杯”课外学术科技作品竞赛获校级奖励并代表学校参加全市比赛。
2015年指导大四本科生毕设获得院级优秀本科生毕业论文奖。
指导的2013和2014级研究生分别获得国家奖学金、优秀研究生奖学金、一等研究生学业奖学金和一等研究生学业优秀奖学金。
2015年“一帮一”先进个人。

联系方式:
办公地点:天津经济技术开发区第十三大街29号亚博网页版登录生物工程院,300457。办公电话:022-60602948;传真:022-60602298;Email: malong@tust.edu.cn。