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教授

 

刘夫锋,博士,亚博APP手机版教授。天津市高校学科领军人才,香江学者。


主讲课程:
本科生:基因工程,生物信息学基础,计算机辅助药物设计与药物信息学
研究生:生物过程的分子模拟

主要教学研究及成果情况
先后主持或参与教改项目2项,参编教材或专著2部,指导国家级大学生创新训练计划1项,指导天津大学大学生创新性实践计划2项。
[1] 亚博网页版登录教育教学改革“创新创业专项”:创新创业教育背景下生物工程专业实验教学内容改革优化研究
[2] 天津大学2014年实验教改项目,生物工程专业实验课教学体系的改革与完善, 2015.01-2015.12
[3] Y. Sun, Q.-H. Shi, L. Zhang, G. Zhao, F. -F. Liu: Adsorption and chromatography. In ed. Comprehensive Biotechnology, Vol. 2, Chapter 2.47. pp. 665-679. Elsevier, 2011.
[4] 贾士儒主编,生物工程专业实验(第二版),中国轻工业出版社,2010
[5] 大学生创新训练计划,淀粉样β蛋白质的高效表达和分离纯化-构建阿尔兹海默症的药物筛选平台,国家级,2017.05-2018.04
[6] 天津大学大学生创新性实践计划,0.3万,2015.01-2015.12
[7] 天津大学大学生创新性实践计划,0.3万,2010.01-2010.12


科研领域及方向
[1] 生物过程的分子模拟 
[2] 蛋白质聚集及抑制 
[3] 酶工程


科研项目情况
[1] 天津市应用基础及前沿技术研究计划重点项目:聚集诱导荧光探针-α-突触核蛋白融合体系构建及其在聚集抑制剂筛选中的应用,2018.04-2021.03 20万
[2] 海河学者:蛋白质聚集及其抑制 2016.04-2019.03 100万
[3] 天津市启动经费, 2017.07-2022.06   50万
[4] 天津市高校学科领军人才培养计划:淀粉样蛋白质聚集抑制剂开发, 2017.09-2020.10  60万
[5] 国家自然科学基金面上项目:细胞膜表面有机小分子抑制淀粉样β多肽构象转换和聚集的多尺度研究,2016.01-2019.12  73万
[6] 国家自然科学基金委-香港研究资助局联合科研资助项目:P-gp介导肿瘤外排紫杉醇的抑制:抑制剂结合位点确定和新型P-gp抑制剂的理性设计,2016.01-2019.12  100万
[7] 国家自然科学基金青年项目:含羟基类渗透剂稳定蛋白质的分子机理研究,2010.01-2012.12  20万
[8] 博士后基金特别资助(香江学者计划):黄酮类二聚体作为抵抗癌症的多药耐药逆转剂,2013.03-2015.06  10万
[9] 博士后基金一等资助,精氨酸衍生物抑制蛋白质聚集的分子模拟研究,2013.05-2015.06  8万
[10] 天津市应用基础及前沿技术研究计划,亲和短肽配基的理性设计和高通量筛选,2010.04-2013.03  10万
[11] 天津大学自主创新基金,P-糖蛋白的多药耐药性及其抑制的分子机理,2010.01-2011.12 5万


主要学术成果
先后发表SCI检索科研论文50余篇,授权或申请发明专利7项。发表的主要学术论文有:
[1] N. Xiong, X.-Y. Dong, J. Zheng, F.-F. Liu*, and Y. Sun*. Design of LVFFARK and LVFFARK- functionalized nanoparticles for inhibiting amyloid β-protein fibrillation and cytotoxicity, ACS Applied Materials & Interfaces, 2015, 7(10): 5650-5662, SCI 1区, Impact factor: 8.097
[2] Junying Wang, Ying Zhang, Xingji Wang, Jinzhao Shang, Yu Li, Huitu Zhang, Fuping Lu*, F.-F. Liu*. Biochemical characterization and molecular mechanism of acid denaturation of a novel α-amylase from Aspergillus niger, Biochemical Engineering Journal, 2018, 137: 222-231. SCI 2区, Impact factor: 3.226 
[3] H. Qin, Z. Zhu, Z. Ma, P. Xu, Q. Guo, S. Li, J. Wang, S. Mao, F.-F. Liu*, F.-P. Lu*. Rational design of cholesterol oxidase for efficient bioresolution of cholestane skeleton substrates, Scientific Reports, 2017, 7: 16375, SCI 3区, Impact factor: 4.122
[4] Y.-L. Tu, S. Ma, F.-F. Liu*, Y. Sun, X.-Y. Dong*. Hematoxylin Suppresses Amyloid β-Protein Aggregation and Reduces Amyloid Cytotoxicity, The Journal of Physical Chemistry B, 2016, 120 (44), 11360–11368. SCI 2区, Impact factor: 3.603 
[5] N. Zhang, F.-F. Liu*, X.-Y. Dong, and Y. Sun*. Synergistic inhibition of acid-induced protein denaturation by trehalose and NaCl: thermodynamic and kinetic studies, Biochemical Engineering Journal, 2014, 91: 231-239, SCI 2区, Impact factor: 3.226
[6] W.-J. Du, J.-J. Guo, M.-T. Gao, S.-Q. Hu, X.-Y. Dong, Y.-F. Han, F.-F. Liu*, S. Jiang*, Y. Sun*. Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity, Scientific Reports, 2015, 5: 7992. SCI 2区, Impact factor: 5.578 
[7] N. Xiong, X.-Y. Dong, J. Zheng, F.-F. Liu*, and Y. Sun*. Design of LVFFARK and LVFFARK-functionalized nanoparticles for inhibiting amyloid β-protein fibrillation and cytotoxicity, ACS Appl. Mater. Inter. 2015, 7(10): 5650-5662. SCI 1区, Impact factor: 7.145 
[8] N. Zhang, F.-F. Liu*, X.-Y. Dong, and Y. Sun*. Synergistic inhibition of acid-induced protein denaturation by trehalose and NaCl: thermodynamic and kinetic studies, Biochemical Engineering Journal, 2014, 91: 231-239. SCI 2区, Impact factor: 2.467 
[9] W.-W. Zhao, F.-F. Liu*, Q.-H. Shi, X.-Y. Dong, and Y. Sun*. Biomimetic design of affinity peptide ligands for human IgG based on Protein A-IgG complex. Biochemical Engineering Journal, 2014, 88: 1-11. SCI 2区, Impact factor: 2.467 
[10] N. Zhang, F.-F. Liu*, X.-Y. Dong, and Y. Sun*. Counteraction of Trehalose on Urea-Induced Protein Unfolding: Thermodynamic and Kinetic Studies, Biochemical Engineering Journal, 2013, 79(15): 120-128. SCI 2区, Impact factor: 2.467 
[11] J.-J. Guo#, W.-Q. Sun#, F.-F. Liu*. Brazilin inhibits the Zn2+-mediated aggregation of amyloid β-protein and alleviates cytotoxicity, Journal of Inorganic Biochemistry 2017, 177: 183-189, SCI 2区, Impact factor:3.063
[12] S.-Y. Chang, F.-F. Liu*, X.-Y. Dong, and Y. Sun*. Molecular insight into conformational transmission of human P-glycoprotein, The Journal of Chemical Physics, 2013,139(22):225102. (Cover page) ,SCI 2区, Impact factor: 3.122 
[13] F.-F. Liu, B. Huang, X.-Y. Dong, and Y. Sun*. Molecular Basis for the Dissociation Dynamics of Protein A-Immunoglobulin G1 Complex. Plos One, 2013, 8(6): e66935. SCI 2区, Impact factor: 4.411 
[14] N. Zhang, F.-F. Liu*, X.-Y. Dong, and Y. Sun*. Equilibrium and kinetic studies of the counteraction of trehalose on acid-induced protein unfolding. Biochemical Engineering Journal, 2013, 70: 188-195. SCI 2区, Impact factor: 2.467 
[15] N. Zhang, F.-F. Liu*, X.-Y. Dong, and Y. Sun*. Molecular Insight into the Counteraction of Trehalose on Urea-Induced Protein Denaturation Using Molecular Dynamics Simulation. The Journal of Physical Chemistry B, 2012, 116: 7040-7047. SCI 2区, Impact factor: 3.603 
[16] F.-F. Liu, Z. Liu, S. Bai, X.-Y. Dong, and Y. Sun*. Exploring the inter-molecular interactions in amyloid-β protofibril with molecular dynamics simulations and molecular mechanics Poisson-Boltzmann surface area free energy calculations. The Journal of Chemical Physics, 2012, Apr 14; 136 (14):145101. SCI 2区, Impact factor: 3.122 
[17] S.-H. Wang, F.-F., Liu, X.-Y. Dong, Y. Sun*. Calorimetric and Spectroscopic Studies of the Interactions between Insulin and (-)-Epigallocatechin-3-gallate. Biochemical Engineering Journal, 2012, 62: 70-78. SCI 2区, Impact factor: 2.467 
[18] B. Huang, F.-F. Liu*, X.-Y. Dong, Y. Sun*. Molecular Mechanism of the Effects of Salt and pH on the Affinity between Protein A and Human Immunoglobulin G1 Revealed by Molecular Simulations, The Journal of Physical Chemistry B, 2012, 116, 424-433. SCI 2区, Impact factor: 3.603 
[19] Y. Sun*, Q.-H. Shi, L. Zhang, G. Zhao, F. -F. Liu: Adsorption and chromatography. In ed. Comprehensive Biotechnology, Vol. 2, Chapter 2.47. pp. 665-679. Elsevier, 2011. 
[20] F.-F. Liu, X. -Y. Dong, L. Z. He, A. P. J. Middelberg, Y. Sun*: Molecular Insight into Conformational Transition of Amyloid β-Peptide 42 Inhibited by (-)-Epigallocatechin-3-gallate Probed by Molecular Simulations. The Journal of Physical Chemistry B, 2011, 115, 11879-11887. SCI 2区, Impact factor: 3.603 
[21] B. Huang, F.-F. Liu, X.-Y. Dong, Y. Sun*. Molecular Mechanism of the Affinity Interactions between Protein A and Human Immunoglobulin G1 Revealed by Molecular Simulations. The Journal of Physical Chemistry B, 2011, 115, 4168-4176. SCI 2区, Impact factor: 3.603 
[22] S.-H. Wang, F.-F., Liu, X.-Y. Dong, Y. Sun*. Thermodynamic Analysis of the Molecular Interactions between Amyloid β-Peptide 42 and (-)-Epigallocatechin-3-gallate. The Journal of Physical Chemistry B, 2010, 114: 11576-11583. SCI 2区, Impact factor: 3.603 
 [23] F.-F. Liu, J. Luo, L. Zhang, X.-Y. Dong, Y. Sun*: Molecular basis for polyol-induced protein stability revealed by molecular dynamics simulations. Journal of Chemical Physics, 2010, 132: 225103. SCI 2区, Impact factor: 3.122 
[24] F.-F. Liu, J. Luo, X.-Y. Dong, Y. Sun*: BIOT 146-Molecular dynamics simulation of the inhibition effect of trehalose on the nucleation and elongation of amyloid beta-peptide oligomers. Abstracts of papers of the American Chemical Society, Vol: 238, 146-BIOT, Aug 16 2009. SCI检索 
[25] F.-F. Liu, J. Luo, X.-Y. Dong, Y. Sun*: Molecular insight into the inhibition effect of trehalose on the nucleation and elongation of Amyloid β-peptide oligomers. The Journal of Physical Chemistry B, 2009, 113 (32): 11320-11329. SCI 2区, Impact factor: 3.603 
[26] Y. Sun*, F.-F. Liu, Q.-H. Shi: Approaches to high-performance preparative chromatography of proteins, Advances in Biochemical Engineering /Biotechnology, 2009, 113: 217-254. SCI 2区, Impact factor: 2.600 
[27] F.-F. Liu, X.-Y. Dong, Y. Sun*: Molecular mechanism for the effects of trehalose on β-hairpin folding revealed by molecular dynamics simulation. Journal of Molecular Graphics & Modelling, 2008, 27 (4): 421-429. SCI 3区, Impact factor: 2.177 
[28] F.-F. Liu, X.-Y. Dong, Y. Sun*: Discovery and design of affinity ligands for protein chromatography. Journal of Biotechnology, 2008, 136: 497. SCI 2区, Impact factor: 3.037 
[29]  F.-F. Liu, X.-Y. Dong, T. Wang, Y. Sun*: Rational design of peptide ligand for affinity chromatography of tissue-type plasminogen activator by the combination of docking and molecular dynamics simulations. Journal of Chromatography A, 2007, 1175 (2): 249-258. SCI 2区, Impact factor: 4.467 
[30]  F.-F. Liu, T. Wang, X.-Y. Dong, Y. Sun*: Rational design of affinity peptide ligand by flexible docking simulation. Journal of Chromatography A, 2007, 1146 (1): 41–50. SCI 2区, Impact factor: 4.467 

授权发明专利主要有:
[1] Yan Sun, Wei-Wei Zhao, Fu-Feng Liu, Qing-Hong Shi. A novel affinity peptide library of IgG constructed based on protein A affinity model and the application of the design method thereof. USA Patent. PTO/AIA/14 (03-13).
[2] 孙彦, 赵韦韦, 刘夫锋, 史清洪. 基于蛋白A亲和模型构建免疫球蛋白G的亲和配基多肽库及设计方法方法的应用. 专利号:ZL201210561815.8,授权公告日:2015.06.24

获奖情况
先后荣获天津大学本科毕业设计优秀指导教师、Hong Kong Scholars Annual Symposium, Best poster、津大学北洋学者青年骨干教师(第一批)、天津大学第九届青年教师讲课大赛,天津大学三等奖、天津大学第九届青年教师讲课大赛,化工学院一等奖、宝舜奖教金、天津大学大学生创新性实践计划项目优秀指导教师、天津大学本科毕业设计优秀指导教师。

联系方式
办公地点:天津经济技术开发区第十三大街29号亚博APP手机版
邮政编码:300457
办公电话:022-60602717
传 真:022-60602298
Email:fufengliu@tust.edu.cn