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副教授

于爱群,博士,硕士生导师,亚博APP手机版教授。亚博网页版登录海河学者培育计划人选。


主讲课程:
本科生:发酵工程、酵母工艺学、酿酒技术概论
研究生:科技论文写作


科研领域及方向:
目前主要从事酿酒酵母和非常规酵母代谢工程和合成生物学领域的研究工作,研究兴趣主要集中于: 利用系统代谢工程和合成生物学技术改造常规酵母和非常规酵母底盘细胞异源生产生物燃料、生物化学品、药物、工业酶和药用蛋白的途径组装及适配策略的研究。


科研情况:
[1] 天津市自然科学基金绿色通道项目;代谢工程改造解脂耶氏酵母生物合成功能性倍半萜化合物;2017-10到2020-09;项目负责人。
[2] 天津市教委科研计划项目重点项目;代谢工程改造解脂耶氏酵母生物合成功能性单萜化合物;2017-05到2020-04;项目负责人。
[3] 亚博网页版登录“海河学者”培育计划引进人才基金;代谢工程改造解脂耶氏酵母生产天然活性单萜;2017-01到2020-12;项目负责人。
[4] 南开大学分子微生物学与技术教育部重点实验室开放课题;解脂耶氏酵母异源合成单萜;2017-09到2019-08;项目负责人。


主要学术成果:
先后发表各类科研论文23篇,申请美国专利2项,中国专利3项。


发表的主要学术论文有:
[1] Aiqun Yu*, Yu Zhao, Jian Li, Shenglong Li, Yaru Pang, Yakun Zhao, Cuiying Zhang, Dongguang Xiao. Sustainable production of FAEE-biodiesel using the oleaginous yeast Yarrowia lipolytica, MicrobiologyOpen, 2020, 00: e1051. (IF: 2.738)
[2] Tee-Kheang Ng#, Aiqun Yu#, Hua Ling, Nina Kurniasih Pratomo Juwono, Won Jae Choi, Su-sanna Su Jan Leong, Matthew Wook Chang*. Engineering Yarrowia lipolytica towards food waste bioremediation: Production of fatty acid ethyl esters from vegetable cooking oil. Journal of Bioscience and Bioengineering, 2020, 129(1): 31-40. (IF: 2.032)
[3] Yaru Pang, Yakun Zhao, Shenglong Li, Yu Zhao, Jian Li, Zhihui Hu, Cuiying Zhang, Dongguang Xiao, Aiqun Yu*. Engineering the oleaginous yeast Yarrowia lipolytica to produce limonene from waste cooking oil. Biotechnology for Biofuels, 2019, 12: 241. (IF: 5.452)
[4] Aiqun Yu#*, Yakun Zhao, Yaru Pang, Zhihui Hu, Cuiying Zhang, Dongguang Xiao, Matthew Wook Chang, Susanna Su Jan Leong. An oleaginous yeast platform for renewable 1-butanol synthesis based on a heterologous CoA dependent pathway and an endogenous pathway. Microbial Cell Factories, 2018, 17: 166. (IF: 4.402)
[5] Aiqun Yu#, Nina Kurniasih Pratomo Juwono, Jee Loon Foo, Susanna Su Jan Leong, Matthew Wook Chang*. Metabolic engineering of Saccharomyces cerevisiae for the overproduction of short branched-chain fatty acids. Metabolic Engineering, 2016, 34: 36-43. (IF: 7.808)
[6] Aiqun Yu#, Nina Kurniasih Pratomo Juwono, Tee-Kheang Ng, Hua Ling, Han-Saem Cho, Su-sanna Su Jan Leong, Matthew Wook Chang*. Genetic engineering of an unconventional yeast for renewable biofuel and biochemical production. Journal of Visualized Experiments, 2016, 115: e54371. (IF: 1.108)
[7] Aiqun Yu#, Nina Kurniasih Pratomo Juwono, Susanna Su Jan Leong, Matthew Wook Chang*. Production of fatty acid-derived valuable chemicals in synthetic microbes. Frontiers in Bioengineering and Biotechnology, 2014, 2: 78. (IF: 5.122)
[8] Aiqun Yu#, Jianchun Zhu, Biao Zhang, Laijun Xing, Mingchun Li*. Knockout of fatty acid desaturase genes in Pichia pastoris GS115 and its effect on the fatty acid biosynthesis and physio-logical consequences. Archives of Microbiology, 2012, 194(12): 1023-1032. (IF: 1.642)
[9] Aiqun Yu#, Tonglei Shi, Biao Zhang, Laijun Xing, Mingchun Li*. Transcriptional regulation of desaturase genes in Pichia pastoris GS115. Lipids, 2012, 47(11): 1099-1108. (IF: 2.144)
[10] Aiqun Yu#, Jianchun Zhu, Biao Zhang, Laijun Xing, Mingchun Li*. Effects of different carbon sources on the growth, fatty acids production, and expression of three desaturase genes of Mortierella alpina ATCC 16266. Current Microbiology, 2011, 62(5): 1617-1622. (IF: 1.595)
[11] 于爱群#*, 马立娟, 郭学武, 董健, 肖冬光. 主题研讨模式在“合成生物学导论”课程中的应用. 高校生物学教学研究(电子版), 2019, 9(1): 30-34.
[12] 于爱群#*, 庞亚如, 胡智慧, 肖冬光. 平台化学品短链支链脂肪酸和短链支链醇的微生物代谢工程. 微生物学通报, 2018, 45(1): 173-180.
[13] 庞亚如#, 胡智慧, 肖冬光, 于爱群*. 柠檬烯和红没药烯的微生物代谢工程. 生物工程学报, 2018, 34(1): 24-33.
[14] 于爱群#, 石桐磊, 张飙, 邢来君, 李明春*. 低温和外源不饱和脂肪酸对高山被孢霉脂肪酸脱氢酶基因表达的影响, 微生物学报, 2012, 52(11): 1369-1377.
[15] 于爱群#, 江贤章, 夏晓峰, 吴松刚, 黄建忠*. γ-亚麻酸产生菌Mucor sp. EIM-10的筛选及分子鉴定, 生物加工过程, 2009, 7(2): 74-78.
[16] Xue Lin#, Aiqun Yu, Cuiying Zhang*, Li Pi, Xiaowen Bai, Dongguang Xiao*. Functional analysis of the global repressor Tup1 for maltose metabolism in Saccharomyces cerevisiae: different roles of the functional domains. Microbial Cell Factories, 2017, 16: 194. (IF: 4.402)
[17] Tonglei Shi#, Aiqun Yu, Ming Li, Meng Zhang, Laijun Xing, Mingchun Li*. Identification and characterization of a novel C20-elongase gene from the marine microalgae, Pavlova viridis, and its use for the reconstitution of two pathways of long-chain polyunsaturated fatty acids biosynthesis in Saccharomyces cerevisiae. Biotechnology Letters, 2013, 35(8): 1271-1282. (IF: 2.154)
[18] Tonglei Shi#, Aiqun Yu, Ming Li, Xiuyuan Ou, Laijun Xing, Mingchun Li*. Identification of a novel C22-Δ4-producing docosahexaenoic acid (DHA) specific polyunsaturated fatty acid de-saturase gene from Isochrysis galbana and its expression in Saccharomyces cerevisiae. Biotechnology Letters, 2012, 34(12): 2265-2274. (IF: 2.154)
[19] Wei Suong Teo#, Hua Ling, Aiqun Yu, Matthew Wook Chang*. Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid short- and branched-chain alkyl esters bio-diesel. Biotechnology for Biofuels, 2015, 8: 177. (IF: 5.452)
[20] Jianzhong Huang#*, Xianzhang Jiang#, Xiaofeng Xia#, Aiqun Yu, Ruoyu Mao, Xiaofeng Chen, Baoyu Tian. Cloning and functional identification of delta5 fatty acid desaturase gene and its 5’-upstream region from marine fungus Thraustochytrium sp. FJN-10. Marine Biotechnology, 2011, 13(1): 12-21. (IF: 2.798)
[22] 胡智慧#, 谌柄旭, 于爱群, 肖冬光*. 代谢工程改造酿酒酵母合成植物萜类D-柠檬烯的策略. 微生物学报, 2018, 58(9): 1542-1550.
[22] 胡智慧#, 翁彦如, 谌柄旭, 于爱群, 肖冬光*. 萜类合成酶定向进化的新思路. 微生物学报, 2019, 59(4): 591-600.
[23] 兰昊#, 欧秀元, 黎明, 于爱群, 石桐磊, 邢来君, 李明春*. 高山被孢霉Δ6-脂肪酸脱氢酶基因在巴斯德毕赤酵母中的表达. 南开大学学报(自然科学版), 2013, 46(2): 100-106.


专利情况:
[1] Matthew Wook Chang, Aiqun Yu, Nina Kurniasih Pratomo Juwono. Method of engineering microorganisms for the overproduction of short branched-chain fatty acids. Reference number: [US Provisional Patent Application No. 62/405,502], 2016-10-07.
[2] Matthew Wook Chang, Aiqun Yu, Nina Kurniasih Pratomo Juwono. Development of a novel yeast platform for 1-butanol synthesis. Reference number: [US Provisional Patent Application No. 62/432,472], 2016-11-17.
[3] 于爱群, 庞亚如, 赵雅坤, 张翠英, 肖冬光. 一株产柠檬烯的解脂耶氏酵母及其构建方法与应用 (申请号:201810441360.3),2018-05-10.
[4] 于爱群,李建,赵禹,肖冬光. 一种生产柠檬烯的解脂耶氏酵母工程菌(申请号:201910948468.6),2019-10-08.
[5] 于爱群,赵雅坤,李建,李圣龙,赵禹,朱坤,张翠英,肖冬光. 一种产红没药烯的解脂耶氏酵母及其构建方法与用途(申请号:201911169971.8),2019-11-26.

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Email: yuaiqun@tust.edu.cn